Based on the original cartoons, the show revolves around the professional and private adventures of three bachelor nurses in a Dutch hospital. Fatima is pretty, but pretentious, picky and insecure, even about having dumped perfect fiancé Jeroen. Nienke is fat and blunt, but optimistic. Stella is a ruthless man-eater. Their matron Wilma, gentleman-MD Jurriaan and gay nurse Thomas all find the trio quite a handful.